| 1691 | Father Kino first visits Tumacacori. |
| 1701 | Tumacacori becomes a visita of Guevavi. |
| 1751 | The Pima rebellion. |
| 1752 | Presidio established at Tubac. |
| 1757 | Reference to a Jesuit church at Tumacacori. |
| 1767 | Expulsion of Jesuits from New Spain. |
| 1768 | Franciscans placed in charge in Pimeria Alta. |
| 1773 | Tumacacori becomes head mission for the district. |
| 1776 | Apaches raid Tumacacori and cause much damage. |
| 1786 | Viceroy Galvez introduces policy of appeasement toward Apaches. |
| 1796 | A Tumacacori census. |
| 1806 | Present church under construction. |
| 1807 | Tumacacori lands increased to over 52,000 acres. |
| 1821 | Mexico declares independence from Spain. |
| 1822 | Present church now in use. |
| 1827 | Tumacacori probably loses last resident priest. |
| 1834 | Mexico requires secularization of missions. |
| 1844 | Treasury department of Sonora sells Tumacacori as "abandoned" Pueblo lands. |
| 1847 | Last church records by visiting priest. |
| 1848 | Indians abandon Tumacacori and move to San Xavier. |
| 1856 | Tubac becomes field headquarters for mining company. |
| 1861 | Civil War starts, Tubac abandoned. |
| 1863 | Arizona becomes part of Confederacy; becomes Arizona Territory, becomes part of the Union. |
| 1886 | Surrender of Geronimo and official end of Apache wars. |
| 1898 | Supreme Court declares Tumacacori lands public domain, hence open to homesteading. |
| 1908 | Homesteader Carmen Mendez relinquishes parcel of land, and President Theodore Roosevelt proclaims Tumacacori National Monument. |
| 1914 | Involved "Baca Float" controversy causes Supreme Court to invalidate homestead entries and government's title to Tumacacori. |
| 1917 | Bouldin and Bailey families deed Tumacacori National Monument lands to government, thus clearing title. |